Article
The impact of SF3B1 mutations in CLL on the DNA-damage response.
Leukemia - 1 May 2015
Te Raa G D, Derks I A M, Navrkalova V, Skowronska A, Moerland P D, van Laar J, Oldreive C, Monsuur H, Trbusek M, Malcikova J, Lodén M, Geisler C H, Hüllein J, Jethwa A, Zenz T, Pospisilova S, Stankovic T, van Oers M H J, Kater A P, Eldering E
Abstract excerpt
Mutations or deletions in TP53 or ATM are well-known determinants of poor prognosis in chronic lymphocytic leukemia (CLL), but only account for approximately 40% of chemo-resistant patients. Genome-wide sequencing has uncovered novel mutations in the splicing factor sf3b1, that were in part associated with ATM aberrations, suggesting functional synergy. We first performed detailed genetic analyses in a CLL cohort...
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