Article
Inherited disorders of the skin in human and mouse: from development to differentiation.
The International journal of developmental biology - 1 Jan 2004
O'Shaughnessy Ryan F L, Christiano Angela M
Abstract excerpt
The last ten years has revealed some of the key players in the development and differentiation of the hair follicle and the epidermis in general. In this review, we discuss how our current understanding of these processes has been made possible by the elucidation of the molecular basis of human inherited diseases and mouse mutants which display defects in the hair and epidermis. For examples, the study of...
Topics
- Alopecia
- Animals
- Basal Cell Nevus Syndrome
- Cell Differentiation
- Epidermis
- Forecasting
- Genetic Predisposition to Disease
- Humans
- Keratins
- Keratosis
- Mice
- Mice, Transgenic