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NF-κB-induced KIAA1199 promotes survival through EGFR signalling

4 Nov 2014

Abstract excerpt

Constitutive activation of EGFR- and NF-κB-dependent pathways is a hallmark of cancer, yet signalling proteins that connect both oncogenic cascades are poorly characterized. Here we define KIAA1199 as a BCL-3- and p65-dependent gene in transformed keratinocytes. KIAA1199 expression is enhanced on human papillomavirus (HPV) infection and is aberrantly expressed in clinical cases of cervical (pre)neoplastic...

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PMID: 25366117
DOI: 10.1038/ncomms6232

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