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Mutant forms of Escherichia coli protein L25 unable to bind to 5S rRNA are incorporated efficiently into the ribosome in vivo.

Biochemistry. Biokhimiia - 1 Aug 2014

Anikaev A Y, Korepanov A P, Korobeinikova A V, Kljashtorny V G, Piendl W, Nikonov S V, Garber M B, Gongadze G M

Abstract excerpt

5S rRNA-binding ribosomal proteins of the L25 family are an evolutional acquisition of bacteria. Earlier we showed that (i) single replacements in the RNA-binding module of the protein of this family result in destabilization or complete impossibility to form a complex with 5S rRNA in vitro; (ii) ΔL25 ribosomes of Escherichia coli are less efficient in protein synthesis in vivo than the control ribosomes. In the...

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PMID: 25365493
DOI: 10.1134/S0006297914080112

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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