Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

FOXO1 locus and acetylcholinesterase inhibitors in elderly patients with Alzheimer's disease.

Clinical interventions in aging - 1 Jan 2014

Paroni Giulia, Seripa Davide, Fontana Andrea, D'Onofrio Grazia, Gravina Carolina, Urbano Maria, Cascavilla Leandro, Pellegrini Fabio, Greco Antonio, Pilotto Alberto

Abstract excerpt

OBJECTIVE: Acetylcholinesterase inhibitors (AChEIs) may reduce the oxidative stress in brain of Alzheimer's disease (AD) patients. Forkhead box O1 (FOXO1) protein has been reported as the link between oxidative stress and AD. We evaluated a potential association between FOXO1 gene locus and the response to AChEI treatment in patients with sporadic AD. METHODS: In this prospective study, 109 Caucasian AD patients...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Cholinesterase Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Forkhead Box Protein O1

Share to Forkhead Transcription Factors

Share to Genetic Loci

Share to Indans

Share to Oxidative Stress

Share to Piperidines

Source

Open in PubMed Open full text

Identifiers

PMID: 25364236
DOI: 10.2147/CIA.S64758
PMCID: PMC4211854

Genes

FOXO1
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

FOXO1 locus and acetylcholinesterase inhibitors in elderly patients with Alzheimer's disease.PMID 25364236Read ↗

Effect of Apolipoprotein E ɛ4 Carrier Status on Cognitive Response to Acetylcholinesterase Inhibitors in Patients with Alzheimer's Disease: A Systematic Review and Meta-Analysis.Semantic proximity Read ↗

APOE-ɛ4 Carrier Status and Donepezil Response in Patients with Alzheimer's Disease.Semantic proximity Read ↗

Paraoxonase 1 gene polymorphisms do not influence the response to treatment in Alzheimer's disease.Semantic proximity Read ↗

GxE interactions between FOXO genotypes and drinking tea are significantly associated with prevention of cognitive decline in advanced age in China.Semantic proximity Read ↗

Association of the choline acetyltransferase gene with responsiveness to acetylcholinesterase inhibitors in Alzheimer's disease.Semantic proximity Read ↗

Influence of rs1080985 single nucleotide polymorphism of the CYP2D6 gene on response to treatment with donepezil in patients with Alzheimer&rsquo;s diseaseSemantic proximity Read ↗

Effect of the CYP2D6 and APOE Polymorphisms on the Efficacy of Donepezil in Patients with Alzheimer's Disease: A Systematic Review and Meta-Analysis.Semantic proximity Read ↗

Impact of the CYP2D6 single nucleotide polymorphism on the concentration of and therapeutic response to donepezil in mild-to-moderate Alzheimer's disease.Semantic proximity Read ↗

Association between human paraoxonase 2 protein and efficacy of acetylcholinesterase inhibiting drugs used against Alzheimer's disease.Semantic proximity Read ↗

Cilostazol as an add-on therapy for patients with Alzheimer's disease in Taiwan: a case control study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.