Article
Selective genetic analysis of myoma pseudocapsule and potential biological impact on uterine fibroid medical therapy.
Expert opinion on therapeutic targets - 1 Jan 2015
Di Tommaso Silvia, Massari Serafina, Malvasi Antonio, Vergara Daniele, Maffia Michele, Greco Marilena, Tinelli Andrea
Abstract excerpt
OBJECTIVE: Mutations in Mediator Complex Subunit 12 (MED12) gene are typical genomic aberrations, commonly detected in a high percentage of uterine leiomyomas (ULs). The aim of this investigation was to define the fibroid or non-tumor origin of uterine leiomyoma pseudocapsule (PC) surrounding fibroids and its possible therapeutic targets in uterine fibroid management. RESEARCH DESIGN AND METHODS: A non-randomized...
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