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Article

Suppression of influenza A virus replication in human lung epithelial cells by noncytotoxic concentrations bafilomycin A1

1 Nov 2014

Abstract excerpt

Subcellular trafficking within host cells plays a critical role in viral life cycles, including influenza A virus (IAV). Thus targeting relevant subcellular compartments holds promise for effective intervention to control the impact of influenza infection. Bafilomycin A1 (Baf-A1), when used at relative high concentrations (≥10 nM), inhibits vacuolar ATPase (V-ATPase) and reduces endosome acidification and...

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PMID: 25361566
DOI: 10.1152/ajplung.00011.2014

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