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Pepstatin A alters host cell autophagic machinery and leads to a decrease in influenza A virus production

23 Feb 2011

Abstract excerpt

Autophagy is a survival mechanism that can take place in cells under metabolic stress and through which cells can recycle waste material. Disturbances in autophagic processes appear to be associated with a number of human pathologies, including viral infections. It has been hypothesized that viruses can subvert autophagy in order to penetrate the host cell and replicate. Because it has been suggested that...

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PMID: 21344392
DOI: 10.1002/jcp.22696

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