Article
The role of the strictly conserved positively charged residue differs among the Gram-positive, Gram-negative, and chloroplast YidC homologs.
The Journal of biological chemistry - 19 Dec 2014
Chen Yuanyuan, Soman Raunak, Shanmugam Sri Karthika, Kuhn Andreas, Dalbey Ross E
Abstract excerpt
Recently, the structure of YidC2 from Bacillus halodurans revealed that the conserved positively charged residue within transmembrane segment one (at position 72) is located in a hydrophilic groove that is embedded in the inner leaflet of the lipid bilayer. The arginine residue was essential for the Bacillus subtilis SpoIIIJ (YidC1) to insert MifM and to complement a SpoIIIJ mutant strain. Here, we investigated...
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