Article
Autophagy controls BCG-induced trained immunity and the response to intravesical BCG therapy for bladder cancer.
PLoS pathogens - 1 Oct 2014
Buffen Kathrin, Oosting Marije, Quintin Jessica, Ng Aylwin, Kleinnijenhuis Johanneke, Kumar Vinod, van de Vosse Esther, Wijmenga Cisca, van Crevel Reinout, Oosterwijk Egbert, Grotenhuis Anne J, Vermeulen Sita H, Kiemeney Lambertus A, van de Veerdonk Frank L, Chamilos Georgios, Xavier Ramnik J, van der Meer Jos W M, Netea Mihai G, Joosten Leo A B
Abstract excerpt
The anti-tuberculosis-vaccine Bacillus Calmette-Guérin (BCG) is the most widely used vaccine in the world. In addition to its effects against tuberculosis, BCG vaccination also induces non-specific beneficial effects against certain forms of malignancy and against infections with unrelated pathogens. It has been recently proposed that the non-specific effects of BCG are mediated through epigenetic reprogramming...
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