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Lysine methyltransferase G9a is an important modulator of trained immunity

1 Jan 2021

Abstract excerpt

Abstract Objectives Histone methyltransferase G9a, also known as Euchromatic Histone Lysine Methyltransferase 2 (EHMT2), mediates H3K9 methylation which is associated with transcriptional repression. It possesses immunomodulatory effects and is overexpressed in multiple types of cancer. In this study, we investigated the role of G9a in the induction of trained immunity, a de facto innate immune memory, and its...

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PMID: 33708384
DOI: 10.1002/cti2.1253

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