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Article

Expansion of the TLO gene family enhances the virulence of Candida species.

PloS one - 1 Jan 2018

Flanagan Peter R, Fletcher Jessica, Boyle Hannah, Sulea Razvan, Moran Gary P, Sullivan Derek J

Abstract excerpt

The TLO genes are a family of subtelomeric ORFs in the fungal pathogens Candida albicans and C. dubliniensis encoding a subunit of the Mediator complex homologous to Med2. The more virulent pathogen C. albicans has 15 copies of the gene whereas the less pathogenic species C. dubliniensis has only two. To investigate if expansion of the TLO repertoire in C. dubliniensis has an effect on phenotype and virulence we...

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Identifiers

PMID: 30028853
DOI: 10.1371/journal.pone.0200852
PMCID: PMC6054389

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Expansion of the TLO gene family enhances the virulence of Candida species.PMID 30028853Read ↗

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