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Article

The role of base excision repair in the development of primary open angle glaucoma in the Polish population.

Mutation research - 1 Aug 2015

Cuchra Magda, Markiewicz Lukasz, Mucha Bartosz, Pytel Dariusz, Szymanek Katarzyna, Szemraj Janusz, Szaflik Jerzy, Szaflik Jacek P, Majsterek Ireneusz

Abstract excerpt

Glaucoma is a leading cause of irreversible blindness in developing countries. Previous data have shown that progressive loss of human TM cells may be connected with chronic exposure to oxidative stress. This hypothesis may suggest a role of the base excision repair (BER) pathway of oxidative DNA damage in primary open angle glaucoma (POAG) patients. The aim of our study was to evaluate an association of BER gene...

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Source

Identifiers

PMID: 26056729
DOI: 10.1016/j.mrfmmm.2015.05.003

Genes

XRCC1
MUTYH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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