Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A microRNA circuit mediates transforming growth factor-β1 autoregulation in renal glomerular mesangial cells.

Kidney international - 1 Aug 2011

Kato Mitsuo, Arce Laura, Wang Mei, Putta Sumanth, Lanting Linda, Natarajan Rama

Abstract excerpt

Enhanced transforming growth factor-β1 (TGF-β1) expression in renal cells promotes fibrosis and hypertrophy during the progression of diabetic nephropathy. The TGF-β1 promoter is positively controlled by the E-box regulators, upstream stimulatory factors (USFs), in response to diabetic (high glucose) conditions; however, it is not clear whether TGF-β1 is autoregulated by itself. As changes in microRNAs (miRNAs)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
Share to Collagen Type I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Collagen Type IV

Share to Diabetes Mellitus, Experimental

Share to Diabetic Nephropathies

Share to Kruppel-Like Transcription Factors

Share to Upstream Stimulatory Factors

Share to Zinc Finger E-box-Binding Homeobox 1

Source

Open in PubMed Open full text

Identifiers

PMID: 21389977
DOI: 10.1038/ki.2011.43
PMCID: PMC3337779

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A microRNA circuit mediates transforming growth factor-β1 autoregulation in renal glomerular mesangial cells.PMID 21389977Read ↗

Potential Targeting of Renal Fibrosis in Diabetic Kidney Disease Using MicroRNAsSemantic proximity Read ↗

MicroRNA Regulation in Renal Interstitial FibrosisSemantic proximity Read ↗

The miR-200 family regulates TGF-β1-induced renal tubular epithelial to mesenchymal transition through Smad pathway by targeting ZEB1 and ZEB2 expressionSemantic proximity Read ↗

Repression of let-7 by transforming growth factor-β1-induced Lin28 upregulates collagen expression in glomerular mesangial cells under diabetic conditions.Semantic proximity Read ↗

MicroRNA-140-5p Mediates Renal Fibrosis Through TGF-β1/Smad Signaling Pathway by Directly Targeting TGFBR1Semantic proximity Read ↗

Intrarenal microRNA signature related to the fibrosis process in chronic kidney disease: identification and functional validation of key miRNAsSemantic proximity Read ↗

MicroRNAs, transforming growth factor beta-1, and tissue fibrosis.Semantic proximity Read ↗

TGF-<i>β</i>1/Smads and miR-21 in Renal Fibrosis and InflammationSemantic proximity Read ↗

Dysregulation of histone H3 lysine 27 trimethylation in transforming growth factor-β1–induced gene expression in mesangial cells and diabetic kidneySemantic proximity Read ↗

MicroRNA193a: An Emerging Mediator of Glomerular DiseasesSemantic proximity Read ↗

miR-299a-5p is a novel mediator of fibrosis in diabetic kidney disease through its regulation of antifibrotic proteins follistatin and cripto-1Semantic proximity Read ↗

CCN2/CTGF increases expression of miR-302 microRNAs, which target the TGFβ type II receptor with implications for nephropathic cell phenotypesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.