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Article

Complement factor I and age-related macular degeneration.

Molecular vision - 1 Jan 2014

Alexander Philip, Gibson Jane, Cree Angela J, Ennis Sarah, Lotery Andrew J

Abstract excerpt

PURPOSE: The complement system has been implicated in the pathogenesis of age-related macular degeneration (AMD). Complement factor I (CFI) is a serum protease that inhibits all complement pathways. A previous multicenter study identified a single missense CFI mutation (p.Gly119Arg) in 20/3,567 (0.56%) of AMD cases versus 1/3,937 (0.025%) of controls, thus suggesting that this mutation confers a high risk of AMD....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25352734
PMCID: PMC4165324

Genes

CFI

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Complement factor I and age-related macular degeneration.PMID 25352734Read ↗

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