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Computational Mutagenesis and Inhibition of Staphylococcus aureus AgrA LytTR Domain Using Phenazine Scaffolds: Insight From a Biophysical Study

1 Jan 2024

Abstract excerpt

Biofilm formation by Staphylococcus aureus is a major challenge in clinical settings due to its role in persistent infections. The AgrA protein, a key regulator in biofilm development, is a promising target for therapeutic intervention. This study investigates the antibiofilm potential of halogenated phenazine compounds by targeting AgrA and explores their molecular interactions to provide insights for drug...

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Share to Antimicrobial Peptides and Activities
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39328594
DOI: 10.1155/2024/8843954

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