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Article

Association between polymorphism of GLI1 gene SNP rs2228226 and chronic lymphocytic leukemia in Chinese population.

Medical oncology (Northwood, London, England) - 1 Dec 2014

Li Yuan-Yuan, Tian Tian, Zhang Run, Wang Li, Xu Ji, Fan Lei, Li Jian-Yong, Xu Wei

Abstract excerpt

A non-synonymous single-nucleotide polymorphism (SNP) (rs2228226C>G), in exon 12 of glioma-associated oncogene homolog 1 (GLI1) (Q1100E), encodes a change from glutamine to glutamic acid (Q1100E). The variant GLI1 protein exhibited reduced transactivation function in vivo, decreasing the ability of activating hedgehog signal, which has been proposed as an unfavorable prognostic marker in chronic lymphocytic...

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PMID: 25352360
DOI: 10.1007/s12032-014-0294-z

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GLI1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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