Molecular evolution of the HIV-1 Thai epidemic between the time of RV144 immunogen selection to the execution of the vaccine efficacy trial.

doi:10.1128/JVI.03070-12

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Article

Molecular evolution of the HIV-1 Thai epidemic between the time of RV144 immunogen selection to the execution of the vaccine efficacy trial.

Journal of virology - 1 Jul 2013

Kijak Gustavo H, Tovanabutra Sodsai, Rerks-Ngarm Supachai, Nitayaphan Sorachai, Eamsila Chirapa, Kunasol Prayura, Khamboonruang Chirasak, Thongcharoen Prasert, Namwat Chawetsan, Premsri Nakorn, Benenson Michael, Morgan Patricia, Bose Meera, Sanders-Buell Eric, Paris Robert, Robb Merlin L, Birx Deborah L, De Souza Mark S, McCutchan Francine E, Michael Nelson L, Kim Jerome H

Abstract excerpt

The RV144 HIV-1 vaccine trial (Thailand, 2003 to 2009), using immunogens genetically matched to the regional epidemic, demonstrated the first evidence of efficacy for an HIV-1 vaccine. Here we studied the molecular evolution of the HIV-1 epidemic from the time of immunogen selection to the execution of the efficacy trial. We studied HIV-1 genetic diversity among 390 volunteers who were deferred from enrollment in...

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PMID: 23576510
DOI: 10.1128/JVI.03070-12
PMCID: PMC3700312

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