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Article

Molecular Mechanisms of Thyroid Dysgenesis

1 Jan 2004

Abstract excerpt

Thyroid dysgenesis (TD) is the most prevalent form of congenital hypothyroidism. Ttf-1, Ttf-2, Pax8 and the Tshr are expressed at early stages of thyroid development and are implicated in thyroid ontogeny. Mutations in these genes have been found in some cases of TD. The prevalence of familial forms of TD is significantly higher than expected if the disease was only sporadic, allowing to postulate a genetic basis...

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PMID: 15539794
DOI: 10.1159/000080494

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