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Article

Cancer in silico drug discovery: a systems biology tool for identifying candidate drugs to target specific molecular tumor subtypes.

Molecular cancer therapeutics - 1 Dec 2014

San Lucas F Anthony, Fowler Jerry, Chang Kyle, Kopetz Scott, Vilar Eduardo, Scheet Paul

Abstract excerpt

Large-scale cancer datasets such as The Cancer Genome Atlas (TCGA) allow researchers to profile tumors based on a wide range of clinical and molecular characteristics. Subsequently, TCGA-derived gene expression profiles can be analyzed with the Connectivity Map (CMap) to find candidate drugs to target tumors with specific clinical phenotypes or molecular characteristics. This represents a powerful computational...

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Identifiers

PMID: 25349306
DOI: 10.1158/1535-7163.MCT-14-0260
PMCID: PMC4341901

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BRAF
EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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