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Article

Narrative review: harnessing molecular genetics for the diagnosis and management of hypertrophic cardiomyopathy.

Annals of internal medicine - 20 Apr 2010

Wang Libin, Seidman Jonathan G, Seidman Christine E

Abstract excerpt

Unexplained cardiac hypertrophy, the diagnostic criterion for hypertrophic cardiomyopathy (HCM), occurs in 1 in 500 adults. Insights into the genetic cause and molecular pathophysiology of HCM are reshaping clinical paradigms for diagnosis and treatment of this common myocardial disorder. Human genetic studies have established that dominant mutations in the proteins that make up the contractile apparatus (the...

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Identifiers

PMID: 20404382
DOI: 10.7326/0003-4819-152-8-201004200-00008
PMCID: PMC3017752

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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