Article
Genetic determinants of responsiveness to mesenchymal stem cell injections in non-ischemic dilated cardiomyopathy.
EBioMedicine - 1 Oct 2019
Rieger Angela C, Myerburg Robert J, Florea Victoria, Tompkins Bryon A, Natsumeda Makoto, Premer Courtney, Khan Aisha, Schulman Ivonne H, Vidro-Casiano Mayra, DiFede Darcy L, Heldman Alan W, Mitrani Raul, Hare Joshua M
Abstract excerpt
BACKGROUND: Non-ischemic dilated cardiomyopathy (NIDCM) responds variably to intramyocardial injection of mesenchymal stem cells (MSCs). We hypothesized that NIDCM genotype may influence responsiveness to MSC therapy and performed genotyping on all patients in the POSEIDON-DCM trial. METHODS: POSEIDON-DCM patients (n = 34) underwent genetic sequence analysis and deletion/duplication testing. The results were...
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