Article
Genomic analysis of reduced susceptibility to tigecycline in Enterococcus faecium.
Antimicrobial agents and chemotherapy - 1 Jan 2015
Cattoir Vincent, Isnard Christophe, Cosquer Thibaud, Odhiambo Arlène, Bucquet Fiona, Guérin François, Giard Jean-Christophe
Abstract excerpt
Tigecycline (TIG) is approved for use for the treatment of complicated intra-abdominal infections, skin and skin structure infections, as well as pneumonia. Acquired resistance or reduced susceptibility to TIG has been observed in Gram-negative rods, has seldom been reported in Gram-positive organisms, and has not yet been reported in Enterococcus faecium. Using the serial passage method, in vitro mutant AusTig...
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