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Article

Prenatal polycyclic aromatic hydrocarbon, adiposity, peroxisome proliferator-activated receptor (PPAR) γ methylation in offspring, grand-offspring mice.

PloS one - 1 Jan 2014

Yan Zhonghai, Zhang Hanjie, Maher Christina, Arteaga-Solis Emilio, Champagne Frances A, Wu Licheng, McDonald Jacob D, Yan Beizhan, Schwartz Gary J, Miller Rachel L

Abstract excerpt

RATIONALE: Greater levels of prenatal exposure to polycyclic aromatic hydrocarbon (PAH) have been associated with childhood obesity in epidemiological studies. However, the underlying mechanisms are unclear. OBJECTIVES: We hypothesized that prenatal PAH over-exposure during gestation would lead to weight gain and increased fat mass in offspring and grand-offspring mice. Further, we hypothesized that altered...

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Source

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Identifiers

PMID: 25347678
DOI: 10.1371/journal.pone.0110706
PMCID: PMC4210202

Genes

PAH
EBP
FAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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