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Article

Novel KCNJ5 mutations in sporadic aldosterone-producing adenoma reduce Kir3.4 membrane abundance.

The Journal of clinical endocrinology and metabolism - 1 Jan 2015

Cheng Chih-Jen, Sung Chih-Chien, Wu Sheng-Tang, Lin Yu-Chun, Sytwu Huey-Kang, Huang Chou-Long, Lin Shih-Hua

Abstract excerpt

CONTEXT: Aldosterone-producing adenoma (APA) has been linked to mutations in the KCNJ5 gene encoding the inward-rectifying potassium (K(+)) Kir3.4 channel. These mutations abolish the K(+) selectivity of Kir3.4 and, consequently, cause sodium (Na(+)) leak, depolarized membrane potential, and nons...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to G Protein-Coupled Inwardly-Rectifying Potassium Channels

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Source

Identifiers

PMID: 25347571
DOI: 10.1210/jc.2014-3009

Genes

KCNJ5

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25347571-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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