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Article

Regulation of aldosterone biosynthesis by the Kir3.4 (KCNJ5) potassium channel.

Clinical and experimental pharmacology & physiology - 1 Dec 2013

Velarde-Miranda Carolina, Gomez-Sanchez Elise P, Gomez-Sanchez Celso E

Abstract excerpt

The G-protein-activated inwardly rectifying potassium channel Kir3.4 is expressed in the zona glomerulosa cell membrane and transports potassium out of the cell. Angiotensin II stimulation of aldosterone secretion is mediated, in part, by suppression of the transcription of KCNJ5, the gene coding for Kir3.4, and blocking channel activity. This results in membrane depolarization, mobilization of intracellular...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23829355
DOI: 10.1111/1440-1681.12151
PMCID: PMC3838480

Genes

KCNJ5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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