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Article

Centrosome dysfunction: a link between senescence and tumor immunity

30 Jun 2020

Abstract excerpt

Centrosome aberrations are hallmarks of human cancers and contribute to the senescence process. Structural and numerical centrosome abnormalities trigger mitotic errors, cellular senescence, cell death, genomic instability and/or aneuploidy, resulting in human disorders such as aging and cancer and affecting immunity. Interestingly, centrosome dysfunction promotes the secretion of multiple inflammatory factors...

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PMID: 32606370
DOI: 10.1038/s41392-020-00214-7

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