Article
[New perspectives for radiosensitization in pancreatic carcinoma: a review of mechanisms involved in pancreatic tumorigenesis].
Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique - 1 Aug 2011
Huguet F, Fernet M, Monnier L, Touboul E, Favaudon V
Abstract excerpt
Pancreatic carcinoma is the fifth leading cause of cancer-related mortality. The 5-year overall survival is less than 5 %. This very poor prognosis can be explained both by late diagnosis and by treatment resistance, including resistance to radiation therapy. A better understanding of the pancreatic tumorigenesis and knowledge of the most frequent mutations in pancreatic adenocarcinoma (KRAS, p16, TP53, Smad4)...
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