Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Immunohistochemistry is highly sensitive and specific for the detection of NRASQ61R mutation in melanoma.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Apr 2015

Massi Daniela, Simi Lisa, Sensi Elisa, Baroni Gianna, Xue Gongda, Scatena Cristian, Caldarella Adele, Pinzani Pamela, Fontanini Gabriella, Carobbio Alessandra, Urso Carmelo, Mandalà Mario

Abstract excerpt

Testing for NRAS is now integral part in the assessment of metastatic melanoma patients because there is evidence that NRAS-mutated patients may be sensitive to MEK inhibitors, and RAS mutation is a common mechanism of acquired resistance during treatment with BRAF inhibitors. This study evaluated the sensitivity and specificity of immunohistochemical analysis using an N-Ras (Q61R) antibody to detect the presence...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over
Share to GTP Phosphohydrolases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immunohistochemistry

Share to Melanoma

Share to Membrane Proteins

Share to Sensitivity and Specificity

Share to Skin Neoplasms

Share to Young Adult

Source

Identifiers

PMID: 25341653
DOI: 10.1038/modpathol.2014.137

Genes

NRAS
BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Immunohistochemistry is highly sensitive and specific for the detection of NRASQ61R mutation in melanoma.PMID 25341653Read ↗

Immunohistochemistry as a potential tool for routine detection of the NRAS Q61R mutation in patients with metastatic melanoma.Semantic proximity Read ↗

Immunohistochemical Detection of NRASQ61R Mutation in Diverse Tumor Types.Semantic proximity Read ↗

NRASQ61R immunohistochemistry detects both NRASQ61R and KRASQ61R mutations in colorectal cancer.Semantic proximity Read ↗

Dual NRASQ61R and BRAFV600E mutation-specific immunohistochemistry completes molecular screening in melanoma samples in a routine practice.Semantic proximity Read ↗

NRASQ61R Mutation-specific Immunohistochemistry is Highly Specific for Either NRAS Q61R or KRAS Q61R Mutation in Colorectal CarcinomaSemantic proximity Read ↗

SP174 Antibody Lacks Specificity for NRAS Q61R and Cross-Reacts With HRAS and KRAS Q61R Mutant Proteins in Malignant Melanoma.Semantic proximity Read ↗

NRAS mutations in primary and metastatic melanomas of Japanese patients.Semantic proximity Read ↗

Immunohistochemistry as a quick screening method for clinical detection of BRAF(V600E) mutation in melanoma patients.Semantic proximity Read ↗

Immunohistochemistry is highly sensitive and specific for the detection of V600E BRAF mutation in melanoma.Semantic proximity Read ↗

Insights into RAS-driven melanoma and its therapeutic implications.Semantic proximity Read ↗

Frequency of mutations in BRAF, NRAS, and KIT in different populations and histological subtypes of melanoma: a systemic reviewSemantic proximity Read ↗

Evaluation of a Rapid, Fully Automated Platform for Detection of BRAF and NRAS Mutations in MelanomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.