Immunohistochemistry as a potential tool for routine detection of the NRAS Q61R mutation in patients with metastatic melanoma.

doi:10.1016/j.jaad.2015.01.012

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Article

Immunohistochemistry as a potential tool for routine detection of the NRAS Q61R mutation in patients with metastatic melanoma.

Journal of the American Academy of Dermatology - 1 May 2015

Ilie Marius, Long-Mira Elodie, Funck-Brentano Elisa, Lassalle Sandra, Butori Catherine, Lespinet-Fabre Virginie, Bordone Olivier, Gay Alexandre, Zahaf Katia, Poissonnet Gilles, Lacour Jean-Philippe, Bahadoran Philippe, Ballotti Robert, Gros Audrey, Dutriaux Caroline, Saiag Philippe, Merlio Jean-Philippe, Vergier Béatrice, Emile Jean François, Hofman Véronique, Hofman Paul

Abstract excerpt

BACKGROUND: It can be useful to assess the NRAS mutation status in patients with metastatic melanoma because NRAS-activating mutations confer resistance to RAF inhibitors, and NRAS-mutated patients appear to be sensitive to mitogen-activated protein kinase (MEK) inhibitors. OBJECTIVE: We aimed to assess the diagnostic accuracy of an immunohistochemistry (IHC) approach using a novel anti-NRAS (Q61R) monoclonal...

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Identifiers

PMID: 25659223
DOI: 10.1016/j.jaad.2015.01.012

Genes

NRAS

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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