Article
Dynamic involvement of ATG5 in cellular stress responses.
Cell death & disease - 23 Oct 2014
Lin H H, Lin S-M, Chung Y, Vonderfecht S, Camden J M, Flodby P, Borok Z, Limesand K H, Mizushima N, Ann D K
Abstract excerpt
Autophagy maintains cell and tissue homeostasis through catabolic degradation. To better delineate the in vivo function for autophagy in adaptive responses to tissue injury, we examined the impact of compromised autophagy in mouse submandibular glands (SMGs) subjected to main excretory duct ligation. Blocking outflow from exocrine glands causes glandular atrophy by increased ductal pressure. Atg5(f/-);Aqp5-Cre...
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