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Article

Growth arrest and autophagy are required for salivary gland cell degradation in Drosophila.

Cell - 14 Dec 2007

Berry Deborah L, Baehrecke Eric H

Abstract excerpt

Autophagy is a catabolic process that is negatively regulated by growth and has been implicated in cell death. We find that autophagy is induced following growth arrest and precedes developmental autophagic cell death of Drosophila salivary glands. Maintaining growth by expression of either activated Ras or positive regulators of the class I phosphoinositide 3-kinase (PI3K) pathway inhibits autophagy and blocks...

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Identifiers

PMID: 18083103
DOI: 10.1016/j.cell.2007.10.048
PMCID: PMC2180345

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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