Article
Gene expression in relation to exhaled nitric oxide identifies novel asthma phenotypes with unique biomolecular pathways.
American journal of respiratory and critical care medicine - 15 Dec 2014
Modena Brian D, Tedrow John R, Milosevic Jadranka, Bleecker Eugene R, Meyers Deborah A, Wu Wei, Bar-Joseph Ziv, Erzurum Serpil C, Gaston Benjamin M, Busse William W, Jarjour Nizar N, Kaminski Naftali, Wenzel Sally E
Abstract excerpt
RATIONALE: Although asthma is recognized as a heterogeneous disease associated with clinical phenotypes, the molecular basis of these phenotypes remains poorly understood. Although genomic studies have successfully broadened our understanding in diseases such as cancer, they have not been widely used in asthma studies. OBJECTIVES: To link gene expression patterns to clinical asthma phenotypes. METHODS: We used a...
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