Article
Novel point mutations and mutational complexes in the enhancer II, core promoter and precore regions of hepatitis B virus genotype D1 associated with hepatocellular carcinoma in Saudi Arabia.
International journal of cancer - 15 Dec 2013
Khan Anis, Al Balwi Mohammed A, Tanaka Yasuhito, Hajeer Ali, Sanai Faisal M, Al Abdulkarim Ibrahim, Al Ayyar Latifah, Badri Motasim, Saudi Dib, Tamimi Waleed, Mizokami Masashi, Al Knawy Bandar
Abstract excerpt
In this study, a cohort of 182 patients [55 hepatocellular carcinoma (HCC) and 127 non-HCC] infected with hepatitis B virus (HBV) in Saudi Arabia was investigated to study the relationship between sequence variation in the enhancer II (EnhII), basal core promoter (BCP) and precore regions of HBV genotype D (HBV/D) and the risk of HCC. HBV genotypes were determined by sequencing analysis and/or enzyme-linked...
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