Article
Hepatitis B virus BCP, Precore/core, X gene mutations/genotypes and the risk of hepatocellular carcinoma in India.
Journal of medical virology - 1 Jul 2010
Asim Mohammad, Malik Abdul, Sarma Manash P, Polipalli Sunil K, Begum Nargis, Ahmad Istaq, Khan Luqman A, Husain S A, Akhtar Naseem, Husain Sajid, Thayumanavan L, Singla Rajiv, Kar P
Abstract excerpt
The study aims to characterize mutations of the HBV genome involving BCP, Precore/core and X regions and also defines HBV genotypes in patients of hepatocellular carcinoma (HCC). The study involved 150 HBV-related HCC cases and 136 HBV-related chronic liver disease patients without HCC as controls. HBV DNA was subjected to mutational analysis using SSCP technique, genotyping by RFLP, and direct nucleotide...
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