Potential antigenic explanation for atypical H1N1 infections among middle-aged adults during the 2013-2014 influenza season.

doi:10.1073/pnas.1409171111

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Article

Potential antigenic explanation for atypical H1N1 infections among middle-aged adults during the 2013-2014 influenza season.

Proceedings of the National Academy of Sciences of the United States of America - 4 Nov 2014

Linderman Susanne L, Chambers Benjamin S, Zost Seth J, Parkhouse Kaela, Li Yang, Herrmann Christin, Ellebedy Ali H, Carter Donald M, Andrews Sarah F, Zheng Nai-Ying, Huang Min, Huang Yunping, Strauss Donna, Shaz Beth H, Hodinka Richard L, Reyes-Terán Gustavo, Ross Ted M, Wilson Patrick C, Ahmed Rafi, Bloom Jesse D, Hensley Scott E

Abstract excerpt

Influenza viruses typically cause the most severe disease in children and elderly individuals. However, H1N1 viruses disproportionately affected middle-aged adults during the 2013-2014 influenza season. Although H1N1 viruses recently acquired several mutations in the hemagglutinin (HA) glycoprotein, classic serological tests used by surveillance laboratories indicate that these mutations do not change antigenic...

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Identifiers

PMID: 25331901
DOI: 10.1073/pnas.1409171111
PMCID: PMC4226110

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