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Article

Predicting clinical severity based on substitutions near epitope A of influenza A/H3N2.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Aug 2015

Lee Hong Kai, Tang Julian Wei-Tze, Loh Tze Ping, Oon Lynette Lin-Ean, Koay Evelyn Siew-Chuan

Abstract excerpt

Epitopes are the main targets for specific antibodies in the host defense systems. Recent studies have shown that amino acid (aa) substitutions located within the influenza A/H3N2 hemagglutinin 1 (HA1) epitopes A-E, particularly in A and B, result in antigenic drift. Viruses with such drift mutations may have resulted in more severe influenza-related illness during influenza epidemics between late 2012 and early...

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PMID: 26118307
DOI: 10.1016/j.meegid.2015.06.025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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