Article
Measuring the effect of inter-study variability on estimating prediction error.
PloS one - 1 Jan 2014
Ma Shuyi, Sung Jaeyun, Magis Andrew T, Wang Yuliang, Geman Donald, Price Nathan D
Abstract excerpt
BACKGROUND: The biomarker discovery field is replete with molecular signatures that have not translated into the clinic despite ostensibly promising performance in predicting disease phenotypes. One widely cited reason is lack of classification consistency, largely due to failure to maintain performance from study to study. This failure is widely attributed to variability in data collected for the same phenotype...
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