A novel methodology for enhanced and consistent heterologous expression of unmodified human cytochrome P450 1B1 (CYP1B1).

doi:10.1371/journal.pone.0110473

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Article

A novel methodology for enhanced and consistent heterologous expression of unmodified human cytochrome P450 1B1 (CYP1B1).

PloS one - 1 Jan 2014

Faiq Muneeb A, Ali Mashook, Dada Tanuj, Dada Rima, Saluja Daman

Abstract excerpt

Cytochrome P450 1B1 (CYP1B1) is a universal cancer marker and is implicated in many other disorders. Mutations in CYP1B1 are also associated with childhood blindness due to primary congenital glaucoma (PCG). To understand the CYP1B1 mediated etiopathology of PCG and pathomechanism of various cancers, it is important to carry out its functional studies. Heterologous expression of CYP1B1 in prokaryotes is...

Topics

Culture Media
Cytochrome P-450 CYP1B1
Escherichia coli
Gene Expression Regulation
Glaucoma
Humans
Membrane Proteins
Mutation
Recombinant Proteins

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Identifiers

PMID: 25329831
DOI: 10.1371/journal.pone.0110473
PMCID: PMC4199734

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