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Article

The Role of Estrogen in Mammary Carcinogenesis<sup>a</sup>

1 Sept 1995

Abstract excerpt

The in vivo and in vitro studies conducted to examine whether E2 functions as an initiator or a promoter in mammary carcinogenesis can be summarized as follows: (1) Clinical and animal studies in vivo have shown a positive correlation of up-regulation of E2 C16 alpha-hydroxylation with either the presence of or the risk for breast cancer, suggesting that this metabolic alteration may represent an early-occurring...

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PMID: 8526389
DOI: 10.1111/j.1749-6632.1995.tb12113.x

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