Article
[Estrogen biosynthesis and receptors].
Annales d'endocrinologie - 1 Nov 1999
Guiochon-Mantel A, Milgrom E, Schaison G
Abstract excerpt
Most of the enzymes involved in steroidogenesis belong to the family of cytochrome P 450. Most of the corresponding genes have been cloned. The key enzyme for estradiol biosynthesis is P 450 arom. Several germline mutations have been described. These observations have lead to reconsider the role of estradiol. Estradiol plays a key role in bone growth and mineralisation and in gonadotrope regulation in male....
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