Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Urinary 2-hydroxyestrone/16alpha-hydroxyestrone ratio and family history of breast cancer in premenopausal women.

Breast cancer research and treatment - 1 Mar 2002

Ursin Giske, London Stephanie, Yang Dongyun, Tseng Chiu-Chen, Pike Malcolm C, Bernstein Leslie, Stanczyk Frank Z, Gentzschein Elisabet

Abstract excerpt

It has been hypothesized that the ratio of urinary 2-hydroxyestrone to 16alpha-hydroxyestrone (2-OHE1/16alpha-OHE1 represents a biomarker for breast cancer risk; the lower the ratio the higher the risk. We obtained early morning urine samples from 70 'high risk' premenopausal women who had a first degree family history of breast cancer and 27 'low risk' women with no such history. Five estrogen metabolites in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers
Share to Breast Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Estradiol

Share to Estrogens

Share to Estrone

Share to Genetic Predisposition to Disease

Share to Premenopause

Source

Identifiers

PMID: 12038704
DOI: 10.1023/a:1014896417653

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Urinary 2-hydroxyestrone/16alpha-hydroxyestrone ratio and family history of breast cancer in premenopausal women.PMID 12038704Read ↗

The ratio of the estradiol metabolites 2-hydroxyestrone (2-OHE1) and 16α-hydroxyestrone (16-OHE1) may predict breast cancer risk in postmenopausal but not in premenopausal women: two case-control studies.Semantic proximity Read ↗

Comparison of estrogens and estrogen metabolites in human breast tissue and urine.Semantic proximity Read ↗

Urinary phytoestrogens and postmenopausal breast cancer risk.Semantic proximity Read ↗

The effect of oral 3,3'-diindolylmethane supplementation on the 2:16α-OHE ratio in BRCA1 mutation carriers.Semantic proximity Read ↗

Association of genetic polymorphisms with serum estrogens measured multiple times during a 2-year period in premenopausal women.Semantic proximity Read ↗

CYP3A7*1C allele is associated with reduced levels of 2-hydroxylation pathway oestrogen metabolites.Semantic proximity Read ↗

Circulating estrogens and estrogens within the breast among postmenopausal BRCA1/2 mutation carriers.Semantic proximity Read ↗

Estrogen hydroxylation--the good and the bad.Semantic proximity Read ↗

Daidzein-metabolizing phenotypes in relation to serum hormones and sex hormone binding globulin, and urinary estrogen metabolites in premenopausal women in the United States.Semantic proximity Read ↗

Polymorphisms in the CYP19 gene may affect the positive correlations between serum and urine phytoestrogen metabolites and plasma androgen concentrations in men.Semantic proximity Read ↗

Excretion of estrogens, catecholestrogens and phytoestrogens in carriers of BRCA1 gene mutations: effects of metformin.Semantic proximity Read ↗

Phytoestrogen exposure is associated with circulating sex hormone levels in postmenopausal women and interact with ESR1 and NR1I2 gene variants.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.