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Multiplexed electrokinetic sensor for detection and therapy monitoring of extracellular vesicles from liquid biopsies of non-small-cell lung cancer patients.

Biosensors & bioelectronics - 1 Dec 2021

Cavallaro Sara, Hååg Petra, Sahu Siddharth S, Berisha Lorenca, Kaminskyy Vitaliy O, Ekman Simon, Lewensohn Rolf, Linnros Jan, Viktorsson Kristina, Dev Apurba

Abstract excerpt

Liquid biopsies based on extracellular vesicles (EVs) represent a promising tool for treatment monitoring of tumors, including non-small-cell lung cancers (NSCLC). In this study, we report on a multiplexed electrokinetic sensor for surface protein profiling of EVs from clinical samples. The method detects the difference in the streaming current generated by EV binding to the surface of a functionalized...

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Identifiers

PMID: 34428672
DOI: 10.1016/j.bios.2021.113568

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