Article
LIM mineralization protein-1 inhibits the malignant phenotypes of human osteosarcoma cells.
International journal of molecular sciences - 23 Apr 2014
Liu Huiwen, Huang Lu, Zhang Zhongzu, Zhang Zhanming, Yu Zhiming, Chen Xiang, Chen Zhuo, Zen Yongping, Yang Dong, Han Zhimin, Shu Yong, Dai Min, Cao Kai
Abstract excerpt
Osteosarcoma (OS), also known as osteogenic sarcoma, is the most common primary malignancy of bone tumor in children and adolescents. However, its underlying molecular pathogenesis is still only vaguely understood. Recently, LIM mineralization protein-1 (LMP-1) was reported to be an essential positive regulator of osteoblast differentiation. In the present study, we found that the expression of LMP-1 is...
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