Article
The double life of p85.
Cancer cell - 13 Oct 2014
Costa Carlotta, Engelman Jeffrey A
Abstract excerpt
A growing number of mutations in PIK3R1, the gene that encodes for the p85α regulatory subunit of PI3K, have been recently identified. In this issue of Cancer Cell, Cheung and colleagues describe two neomorphic PIK3R1 mutants prevalent in endometrial and colon cancer that induce transformation via activation of PI3K-independent pathways.
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