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Article

Impact of CYP2C19 polymorphisms on the antiplatelet effect of clopidogrel in an actual clinical setting in Japan.

Circulation journal : official journal of the Japanese Circulation Society - 1 Aug 2009

Jinnai Toshikazu, Horiuchi Hisanori, Makiyama Takeru, Tazaki Junichi, Tada Tomohisa, Akao Masaharu, Ono Koh, Hoshino Kozo, Naruse Yumiko, Takahashi Kanako, Watanabe Haruyo, Kita Toru, Kimura Takeshi

Abstract excerpt

BACKGROUND: The P2Y(12) adenosine diphosphate (ADP) receptor blocker, clopidogrel, an essential drug for the prevention of stent thrombosis after percutaneous coronary intervention (PCI), is a prodrug that requires CYP2C19- and CYP3A4-mediating activation. CYP2C19*2 and *3 polymorphisms are known to lack enzymatic activity. CYP2C19 polymorphisms have been reported to exhibit weaker antiplatelet response to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19531897
DOI: 10.1253/circj.cj-09-0019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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