Article
Heme Oxygenase-1 and 2 Common Genetic Variants and Risk for Restless Legs Syndrome.
Medicine - 1 Aug 2015
García-Martín Elena, Jiménez-Jiménez Félix Javier, Alonso-Navarro Hortensia, Martínez Carmen, Zurdo Martín, Turpín-Fenoll Laura, Millán-Pascual Jorge, Adeva-Bartolomé Teresa, Cubo Esther, Navacerrada Francisco, Rojo-Sebastián Ana, Rubio Lluisa, Ortega-Cubero Sara, Pastor Pau, Calleja Marisol, Plaza-Nieto José Francisco, Pilo-de-la-Fuente Belén, Arroyo-Solera Margarita, García-Albea Esteban, Agúndez José A G
Abstract excerpt
Several neurochemical, neuropathological, neuroimaging, and experimental data, suggest that iron deficiency plays an important role in the pathophysiology of restless legs syndrome (RLS). Heme-oxygenases (HMOX) are an important defensive mechanism against oxidative stress, mainly through the degradation of heme to biliverdin, free iron, and carbon monoxide. We analyzed whether HMOX1 and HMOX2 genes are related...
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