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Article

Generation of mice lacking DUF1220 protein domains: effects on fecundity and hyperactivity.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Feb 2015

Keeney J G, O'Bleness M S, Anderson N, Davis J M, Arevalo N, Busquet N, Chick W, Rozman J, Hölter S M, Garrett L, Horsch M, Beckers J, Wurst W, Klingenspor M, Restrepo D, de Angelis M Hrabě, Sikela J M

Abstract excerpt

Sequences encoding DUF1220 protein domains show the most extreme human lineage-specific copy number increase of any coding region in the genome and have been linked to human brain evolution. In addition, DUF1220 copy number (dosage) has been implicated in influencing brain size within the human species, both in normal populations and in individuals associated with brain size pathologies (1q21-associated...

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Identifiers

PMID: 25308000
DOI: 10.1007/s00335-014-9545-8
PMCID: PMC4305498

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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