Article
BMP4 was associated with NSCL/P in an Asian population.
PloS one - 1 Jan 2012
Chen Qianqian, Wang Hong, Hetmanski Jacqueline B, Zhang Tianxiao, Ruczinski Ingo, Schwender Holger, Liang Kung Yee, Fallin M Daniele, Redett Richard J, Raymond Gerald V, Wu Chou Yah-Huei, Chen Philip Kuo-Ting, Yeow Vincent, Chong Samuel S, Cheah Felicia S H, Jabs Ethylin Wang, Scott Alan F, Beaty Terri H
Abstract excerpt
BACKGROUND: The Bone Morphogenetic Protein 4 gene (BMP4) is located in chromosome 14q22-q23 which has shown evidence of linkage for isolated nonsyndromic cleft lip with or without cleft palate (NSCL/P) in a genome wide linkage analysis of human multiplex families. BMP4 has been shown to play crucial roles in lip and palatal development in animal models. Several candidate gene association analyses also supported...
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