Article
Curcumin sensitizes prostate cancer cells to tumor necrosis factor-related apoptosis-inducing ligand/Apo2L by inhibiting nuclear factor-kappaB through suppression of IkappaBalpha phosphorylation.
Molecular cancer therapeutics - 1 Jul 2004
Deeb Dorrah, Jiang Hao, Gao Xiaohua, Hafner Mikehl S, Wong Henry, Divine George, Chapman Robert A, Dulchavsky Scott A, Gautam Subhash C
Abstract excerpt
Epidemiologic studies suggest that diet rich in plant-derived foods plays an important role in the prevention of prostate cancer. Curcumin, the yellow pigment in the spice turmeric, has been shown to exhibit chemopreventive and growth inhibitory activities against multiple tumor cell lines. We have shown previously that curcumin and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)/Apo2L interact to...
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